Oncology

Resolve Cancer with single cell and spatial multiomics

Gain a multidimensional view of cancer

Address the true complexities of cancer with sharper resolution into the cell types and states that drive cancer. 10x Genomics develops technologies that illuminate the details and dynamics of this complicated disease.

Dissect the tumor and immune contexture

See how the combination of single cell gene expression and spatial profiling technologies enables researchers to explore tumor heterogeneity and the complex interactions of the tumor microenvironment (TME).

  • Tumor Heterogeneity

    Tumor Heterogeneity

    Build integrated single cell and spatial atlases, unmask intratumoral heterogeneity, and trace transcriptomic and epigenetic modulators of clonal evolution within tumors and across cancer types.
  • Tumor Microenvironment

    Tumor Microenvironment

    Uncover the influence of tissue architecture on cancer progression, immune infiltration, and therapeutic response and identify the epigenetic regulators and transcriptomic programs driving diverse phenotypes and developmental trajectories.
  • Immuno-oncology

    Immuno-oncology

    Advance immunotherapies by characterizing immune cell modulation in tumor progression. Define the receptor repertoire of infiltrating and peripheral immune cells mediating anti-tumor responses.
  • Therapeutic Development

    Therapeutic Development

    Discover novel therapeutic targets, explore how therapeutics modulate cell populations and states within the tumor microenvironment, and understand resistance mechanisms governed by transcriptomic and epigenetic remodeling.
    • Customer Research

    Visualize Cancer in Multiple Dimensions

    Researchers at the Fred Hutchinson Cancer Research Center are using multidimensional single cell analysis to peer deeper into the tumor microenvironment. These technologies are helping them investigate the body’s response to tumors, discover key driver mutations, and inform why treatments fail.

    • View Video
    • View Publication

    Explore featured resources to enhance your oncology research

    • Sample Prep Guide

      Get the most out of your single cell experiments with this essential guide, filled with best practices and useful resources to help you optimize your sample prep.
      • Download Sample Prep Guide

    • Application Note

      Learn how the Chromium Single Cell Immune Profiling Solution was used to uncover the functional phenotype and clonality of tumor-infiltrating immune cells.
      • Download App Note
      • View All Application Notes

    • Poster

      See how spatial gene expression profiling can provide a powerful complement to traditional histopathology, enabling a detailed view of the tumor microenvironment architecture.
      • View Poster
      • View All Posters
    Publications

    Unraveling cancer complexities

    Single cell and spatial tools from 10x Genomics enable cancer researchers to ask and answer deeper questions. See how researchers are using these tools to fundamentally alter our understanding of cancer and accelerate novel translational applications in diagnosis, prognosis, therapeutic development, and treatment.
    Download Cancer Research Highlights

    Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas

    Integrating microarray-based spatial transcriptomics and single-cell RNA-seq reveals tissue architecture in pancreatic ductal adenocarcinomas

    Nature Biotechnology, Jan 2020

    Nature Biotechnology, Jan 2020

    Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

    Massively parallel single-cell chromatin landscapes of human immune cell development and intratumoral T cell exhaustion

    Nature Biotechnology, Aug 2018

    Nature Biotechnology, Aug 2018

    Increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

    Increased intratumoral heterogeneity after the onset of therapy resistance in small-cell lung cancer

    Nature Cancer. 2020, C. Allison Stewart, et al.

    Nature Cancer. 2020, C. Allison Stewart, et al.

    Products for Oncology Research

    • Resolve cancer with single cell and spatial multiomic products from 10x Genomics