Journey deeper into the brain
Gain a richer understanding of the nervous system and accelerate the discovery of fundamental biology driving complicated, multifactorial neurodegenerative, psychiatric, and neurodevelopmental diseases. Explore 10x Genomics single cell and spatial tools for neuroscience in this short video.
Neurodegenerative Disease
Build a complete picture of the complex biology of neurodegenerative diseases in multiple dimensions. Advance your understanding of how pathological features affect the surrounding microenvironment and deepen your insights into the cellular contribution to disease pathogenesis and progression.
Psychiatric Disorders
Discover the molecular foundations of psychiatric disorders with single cell and spatial technologies. Characterize disease-associated cellular phenotypes and uncover novel pathological effects. Explore the regulatory landscape of neural cells and identify epigenetic regulators of discrete cell types and states.
Developmental Neuroscience
Achieve a more detailed view of neural development and differentiation than previously possible. Dissect molecular pathways controlling cellular differentiation, identify novel cell subtype markers, and reveal the dynamic gene expression patterns and regulatory landscapes governing cell differentiation.
TREM2-Associated Cellular Responses in Alzheimer’s Disease
Watch this featured webinar to see how single cell sequencing can reveal novel functional phenotypes of neural cells in disease. Learn about the effects of the Trem2 AD risk variant on distinct cell types, and hear about previously undescribed roles of glia in AD pathogenesis.
Explore featured resources to enhance your neuroscience research
Brochure
Explore how you can gain a better understanding of the cellular and molecular mechanisms underlying both normal brain function and disease with single cell and spatial gene expression tools.
Application Note
Learn how you can characterize large and complex biological tissues, such as the brain, at single cell resolution with Chromium Single Cell Gene Expression.
Poster
See how you can examine gene expression profiles across different brain regions and in the context of disease by combining histological and transcriptomic analyses with Visium Spatial Gene Expression.
Neuroscience revealed: from development to health and disease
Single-cell transcriptomic analysis of Alzheimer’s disease
Single-cell transcriptomic analysis of Alzheimer’s disease
Mathys H et al. Nature. 2019
Mathys H et al. Nature. 2019
Spatiotemporal Dynamics of Molecular Pathology in Amyotrophic Lateral Sclerosis
Spatiotemporal Dynamics of Molecular Pathology in Amyotrophic Lateral Sclerosis
Maniatis S et al. Science. 2019
Maniatis S et al. Science. 2019
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis
Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis
Weng Q et al. Cell Stem Cell. 2019
Weng Q et al. Cell Stem Cell. 2019